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CBD Oil Effects: Eight Disorders CBD Can Help Treat

Janet Miller

Janet Miller

Last updated: December 23, 2019

Shutterstock / Tinnakorn jorruang

Recent studies on CBD oil effects conducted over the last decade have shown that CBD is highly effective in treating the symptoms of illnesses harmful to mental and physical health, including depression, rheumatism, and cancer. The reason why hemp-based oil products are useful is that they reduce inflammation, kill cancer cells, and have neuroprotective properties, among other benefits.

All without getting users high, unlike marijuana. These medicinal benefits make cannabidiol viable for use during the treatment of these illnesses alongside physician-prescribed medications.

What Medical Research Says about CBD Oil Effects?

The increasing legalization and deregulation of hemp-based CBD oil have given researchers opportunities to study how CBD oil affects the human body. As a result of this research, scientists have discovered that it has medicinal properties that can mitigate the symptoms of diseases and mental health disorders.

Pain Relief

Macedonian scientists conducted a meta-analysis of 18 trials and found that 15 of them yielded promising results for cannabidiol. 43 percent of the participants stated that it reduced their pain and that the adverse effects were well tolerated and mild to moderate. The scientists reported that their study demonstrates that it is safe and modestly effective for treating neuropathic pain and relieving pain caused by malignant diseases.

A study conducted by Italian scientists tested the effectiveness of CBD for chronic sciatic nerve constriction and inflammatory pain in rats. The rats were given 2.5 to 20 mg per kg of body weight starting from day seven after their injuries. The researchers observed that hemp had substantial anti-inflammatory and immunomodulatory effects, indicating the potential for using CBD for treating chronic pain.

Scientists in the United Kingdom have been studying CBD’s effectiveness for rheumatoid arthritis. Patients were administered cannabis-based medicine (CBM) in the form of an oromucosal spray in the evening, and the results were recorded in the morning. When compared to the placebo, CBM resulted in more effortless movement, less pain while idle, and better quality of sleep. The side effects were

Anxiety and Depression

Brazilian researchers orally administered cannabidiol to 57 men in a double-blind procedure. Ratings on the Visual Analogue Mood Scale and physiological measures were obtained six times throughout the study. The researchers determined that 300 mg of CBD reduced anxiety during speech when compared with the group taking the placebo.

Doctors in Colorado treated a 10-year-old girl suffering from anxiety and sleeplessness as a result of post-traumatic stress disorder caused by sexual abuse. Pharmaceutical medications were not providing the relief she needed, and they were causing significant side effects. Hemp oil was given to her instead of helping improve her symptoms, and the result was decreased anxiety and improved sleep.

Pharmaceutical medications can help treat mental health issues, but patients are concerned about their side effects, and drugs like benzodiazepines are addictive and can be abused and cause cognitive decline. Cannabinoids are an option for those concerned about the impact of pharmaceutical medications.

177 cancer patients experiencing inadequate analgesia despite taking opioids participated in a two-week study in which they were administered THC/CBD extract, THC extract, or placebo. Patients taking the THC/CBD extract showed more pain reduction than those administered the placebo, while the THC group showed no significant changes in pain levels. The authors of the study showed that THC/CBD extract is useful for cancer-related relieving pain when opioids are ineffective.

A randomized, double-blind phase II clinical trial was conducted to evaluate the effectiveness of CBM containing THC and CBD for controlling chemotherapy-induced nausea and vomiting (CINV). The researchers concluded that CBM enhanced antiemetic therapy and that it protected against CINV. The research team advised moving on to phase II clinical trials.

It can also cause the death of cancerous cells. In 2012, researchers determined that CBD causes cell death in breast cancer cells by coordinating the interaction between apoptosis and autophagy.


One of the causes of acne is sebum overproduction. Sebum is an oily secretion made by the sebaceous glands in the skin. In 2014, scientists explored the effects of CBD on sebaceous glands and concluded that it works well as a sebostatic agent. Their findings suggest that cannabinoids can be used as a natural alternative for treating acne vulgaris.

A 2016 study produced similar results. Scientists determined that cannabinoids not only are effective in treating acne, but they can also be used for treating dry and seborrhoeic skin.

Neuroprotective Properties

American scientists began an open-label trial in 2016 to determine how effective it is at treating epilepsy. Patients ranging from one to 30 years old were given 2 – 5 to 25 – 50 mg per kg per day. The median reduction in monthly seizures was 36.5 percent. These findings suggest that CBD reduces seizure frequency and can be used safely by adults and children.

A 2017 study saw 120 young adults and children with Dravet syndrome given 20 mg of CBD per kg of body weight. The median frequency of seizures decreased from 12.4 to 5.9. 43 percent of patients had a 50 percent reduction in the number of seizures they had. Five percent of patients became seizure-free. The researchers concluded that CBD was more effective in combating seizures than the placebo.

CBD is also useful for treating Alzheimer’s disease. Articles published in 2017 and 2014 state that CBD can prevent neurodegeneration associated with Alzheimer’s and can prevent cognitive decline in mice genetically predisposed to this disease.

Cardiovascular Health

British researchers administered nine men 600 mg of CBD or placebo in a double-blind study and monitored their cardiovascular parameters. The CBD reduced resting systolic blood pressure and stroke volume with increased heart rate and maintained cardiac output. The men were also given tests that increased stress, and the blood pressure increase was low in response to these tests.

In 2011, scientists investigated how it affects myocardial dysfunction, inflammation, oxidative/nitrosative stress, cell death, and interrelated signaling pathways using a mouse model and primary human cardiomyocytes affected by high glucose levels. The results of the study showed that CBD is useful for treating diabetes and cardiovascular disorders by reducing oxidative and nitrosative stress, inflammation, cell death, and fibrosis.

Parkinson’s Disease

21 people with Parkinson’s disease were selected to participate in a study on CBD’s effectiveness for treating their symptoms. The participants were evenly divided into three groups and given 75 or 300 mg of CBD per day. The findings of this study showed that CBD significantly improved the quality of life in these people with Parkinson’s.

In another study using cannabinoids, four patients with Parkinson’s showed a significant reduction in adverse events during sleep without suffering side effects.

Multiple Sclerosis

A study conducted by Italian scientists investigated the effectiveness of Sativex (a drug with THC/CBD) in treating the symptoms of multiple sclerosis. 30 MS patients participated in the study. Their symptoms were assessed before and after the study, and the results were increased intracortical inhibition, reduced spinal excitability, and improved muscle spasticity.

CBD Oil Effects and Bioavailability

Shutterstock / VectorMine

The effectiveness of natural CBD oil products depends on their bioavailability – the rate at which the body absorbs them.

  • The sublingual method of taking hemp oil is very effective, impacting the body faster than other methods because the oil is absorbed through the mouth’s mucous membranes rather than going through the digestive system. During sublingual administration, 12 to 35 percent of the CBD is absorbed by the body.
  • Inhaling CBD oil by vaping or dabbing is another effective way to get CBD into the system. When it is inhaled, it goes through the lungs and enters the bloodstream. Medical studies show that the bioavailability of CBD, when inhaled, is 34 to 46 percent and even as high as 56 percent.

The bioavailability of orally-administered CBD oil is very low, with a 2009 study reporting it to be between four and 20 percent.

Are CBD Oil Products Safe?

One concern people have about hemp-based CBD oil effects is that they may be psychoactive. This concern is unfounded because it is incapable of getting someone high. According to a report published by the World Health Organization, it cannot be abused, nor does it have any potential to make a user high cause dependency.

Are There Any Harmful CBD Oil Effects?

A 2017 report on CBD oil benefits and side effects confirmed that CBD oil was safe for use in humans and that the most common CBD oil side effects were fatigue, diarrhea, and changes in weight and appetite.

This same study also stated that people taking medications with grapefruit warnings should not take hemp-based CBD because it interferes with cytochromes P450, a group of enzymes that are important to drug metabolism. Consult with a doctor if concerned about the side effects of CBD oil.

The US Food and Drug Administration advises women who are pregnant or nursing not to take CBD or any other cannabis products. According to the FDA, there is not enough data available to make a sound determination as to whether expecting and nursing mothers can take CBD oil.

FAQ about CBD Oil Effects and Benefits

How Do CBD Oil Effects Make You Feel?

Considering that CBD is a non-toxic compound, the person will be able to do everyday things: work, drive a car. Some people mentioned that sometimes after taking CBD oil, they feel relaxed and relief from such conditions as pain, nausea, inflammation.

CBD Products Show Up on Drug Tests?

A common worry is that its effects can result in failing a drug test. Pure hemp cannot show up on a drug test since the plants harvested to collect the compound are not allowed to have more than 0.3 percent of THC.

But to avoid unpredictable things, always buy CBD oil products from companies that source their CBD from regulatory compliant farms and have lab tests available.

Can You Take too Much Hemp-Based CBD Oil?

CBD is well-tolerated by humans and that the risk for adverse effects is low. There are mild side effects, but by starting with a small dosage and gradually increasing it over several weeks, adverse reactions can be avoided.

One way first-time users can avoid problems with CBD is to start with a product that has low bioavailability, like edibles. Taking them will give the body time to adjust to this new compound. Once the body is acclimated to CBD, the user can move onto a product with higher bioavailability like tincture oils, vape oils, or waxes.

The legal landscape for cannabidiol users and sellers is very confusing despite the known medical benefits. Congress’s 2018 Farm Bill did legalize CBD, but only if it is made per the stipulations in the bill.

One thing CBD oil users should be concerned about is the legal status of cannabis at the state level. Recreational cannabis is only permitted in:

  • California
  • Washington
  • Nevada
  • Oregon
  • Colorado
  • Illinois
  • Vermont
  • Massachusetts
  • Maine
  • Washington DC

In the states not mentioned, cannabis, including CBD, remains illegal or only legal for medical use. Cannabis users should exercise due diligence when using CBD or any cannabis product. Know what the law says in your jurisdiction before using it.

Final Thoughts about CBD Oil Effects

The studies mentioned herein show that natural hemp-based cannabidiol is beneficial for treating the symptoms of mental health disorders, epilepsy, arthritis, multiple sclerosis, and various other ailments. Better still, hemp-based CBD can help manage these disorders without making users high like marijuana. People suffering from these illnesses undergo significant changes to their lifestyles to mitigate symptoms. Rather than let these symptoms take control of your life, retake control with the help of CBD.

Before deciding to use hemp-based CBD, always consult with a physician, and do not stop taking prescribed medications without his or her advice.

If you have taken cannabidiol for the diseases or disorders about which we have written, please write and tell whether the CBD oil effects were beneficial.


Janet Miller

Janet Miller

Janet is a medical specialist with 10 years of experience as a physician and writing passion. She aims to help people and expand humans mindset. Chat with Janet on Twitter @Janet_Miller_MD or via our contact page.


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